1. Experimental Design: (F) Pilot Runs and Panel Optimization
In flow cytometry, the “eagerness to start” is often the enemy of “good data.” In this article, Aditi Sharma explains why the Pilot Run is a non-negotiable bedrock for your experiment. She tackles the four essential steps for panel optimization to ensure that when you finally run your experimental samples, your data is biologically real, […]
Case Studies for Remote Monitoring Devices
Remote patient monitoring (RPM) is quietly transforming care outside the hospital. In her latest piece, Srividya breaks down 3 powerful case studies: All three have the same theme: when you combine easy‑to‑use devices + real‑time data + proactive care teams, outcomes improve, and hospitals see fewer avoidable admissions. (Click anywhere on the image to expand) […]
DAILY SUPPLEMENTS: IS YOUR BRAIN SAFE?
In this article, Neeba Wilson delves into the rise of self-medication through dietary supplements and its impact on brain health. With health products now readily available in grocery stores, many of us unknowingly mix and match supplements without fully understanding their effects on our brain chemistry. From magnesium’s role in nerve function to the complex […]
1. Experimental Design: (E) Controls and Replicates
Controls and replicates are not optional accessories—they are the security system for your flow cytometry data. In this installment of Flow Focus, Aditi Sharma dissects the essential elements of rigorous experimental design. Move beyond raw data and build a flow cytometry experiment you can truly trust. (Click anywhere on the image to expand) Disclaimer The editors take […]
VENTANA (SP44) RXDX ASSAY
Continuing her series on lung cancer diagnostics, Krishnangi examines the VENTANA MET (SP44) RxDx Assay, an FDA-approved immunohistochemistry companion diagnostic for NSCLC . In this edition, she highlights the assay’s standardized pathology workflow, its role in identifying patients eligible for MET-targeted therapy, and its significance in advancing biomarker-driven treatment selection in precision oncology. (Click anywhere […]
Dual-Payload ADCs, Revisited: When Does a Second Warhead Really Help?
In our latest ADC Spotlight, Suhail Ahmed Kabeer Rasheed revisits dual‑payload ADCs – not to repeat the KH815 story, but to ask a sharper question: when does a second warhead genuinely help, and when is it just extra complexity? Drawing on earlier pieces about formats, site‑specific conjugation, smart linkers, TME‑activated and non‑internalizing ADCs, this article walks through a practical […]
Why Wearables Need Rules: A Simple Guide to Regulatory Affairs in Health Tech
Your smartwatch just alerted you about an irregular heartbeat. But did you know that same device had to navigate a complex maze of FDA regulations, cybersecurity requirements, and privacy laws before reaching your wrist? (Click anywhere on the image to expand) Disclaimer The editors take care to share authentic information. In case of any discrepancies […]
Powering Next-Gen Payload Innovation: Zynlonta
In this edition of ADC Spotlight, Sneha explores Zynlonta, a CD19-directed molecule that marked a leap in ADC evolution with the introduction of a novel PBD payload. By combining precise B-cell targeting with a next-generation cytotoxic warhead, Zynlonta offered a new treatment option for patients with R/R DLBCL. This snapshot captures its story from development […]
How Ocular Fluids Reflect Alzheimer’s Disease Pathology
In this article, Neeba Wilson delves into the research on how ocular fluids can serve as early indicators of Alzheimer’s disease. Drawing on studies published in 2024, learn how biomarkers in tears, aqueous humor, and vitreous humor may provide a non-invasive approach to diagnosing and tracking the disease. Learn how amyloid beta and tau proteins […]
Bipolar Disorder: Pharmacological Targets
Continuing our journey toward understanding bipolar disorder, this article explores ongoing clinical trials and the evolving shift in pharmacological targets. (Click anywhere on the image to expand) Disclaimer The editors take care to share authentic information. In case of any discrepancies please write to newsletter@medness.org. The sponsors do not have any influence on the nature […]
Non-Internalizing ADCs: Targeting the Tumor Microenvironment Itself
Non‑internalizing ADCs turn a long‑standing limitation into an opportunity. In this new Medness article, Suhail Ahmed Kabeer Rasheed explores ADCs that don’t need to enter tumor cells at all—instead, they bind extracellular or stromal targets and use TME‑activated, often self‑immolative linkers to release membrane‑permeable payloads directly into the tumor space. Dense stroma and poor internalization […]
Sola Dosis Facit Venenum: A History of Use and Misuse of a Toxin
The Poison That Heals. Botox, a lethal neurotoxin that doubles as a miracle cure, is a medical paradox. This two-part series dives into the history, science, and dark side of Botox. Part 1covers its rise as a medical marvel, while Part 2 states discuss the growing risks of the unlicensed “Black Market” Read Part: I […]
Why is Regulatory Affairs Needed in Medical Devices?
What stands between a medical device innovation and patient safety? Dive into the complex world of FDA pathways, device classifications, and post-market surveillance that ensures the devices in hospitals today won’t become tomorrow’s recalls. (Click anywhere on the image to expand) Disclaimer The editors take care to share authentic information. In case of any discrepancies […]
Sola Dosis Facit Venenum: A History of Use and Misuse of a Toxin
The Poison That Heals. Botox, a lethal neurotoxin that doubles as a miracle cure, is a medical paradox. This two-part series dives into the history, science, and dark side of Botox. Part: 1 “Alle Dinge sind Gift, und nichts ist ohne Gift; allein die Dosis macht, dass ein Ding kein Gift ist.” — Paracelsus, the Father […]
How Early Brain Inflammation and Immune Changes Shape the Parkinson’s Disease
In this article, Neeba Wilson explores the emerging science behind how Parkinson’s disease may begin years before its hallmark motor symptoms appear. Drawing from new research published in October 2025, learn how early brain inflammation, activated microglia, and immune system changes inside and outside the brain set the stage for neuronal damage. Learn how alpha-synuclein […]
Bipolar Disorder
Extremely high energy today, as if you could capture the world, only to feel completely lost a few weeks later. Bipolar disorder is characterized by this affective instability, oscillating between extreme excitement and depressed states. This article addresses how the condition is defined, along with its symptoms, causes, risk factors, and management. (Click anywhere on […]
Defining Key Flow Cytometry Terms – Part 1
In this article, Aditi Sharma provides a foundational glossary for flow cytometry practitioners. It defines essential terminology, paving the way for our subsequent deep dives into complex topics like multi-parameter panel construction and robust compensation controls. (Click anywhere on the image to expand) Disclaimer The editors take care to share authentic information. In case of […]
TME-Activated Linkers: Giving ADCs Spatial Intelligence
Tumor targets aren’t always the real problem – sometimes it’s the neighborhood they live in. In this week’s Medness ADC Spotlight, Suhail Ahmed Kabeer Rasheed dives into tumor microenvironment (TME)–activated linkers and masked ADCs that don’t just ask “what antigen?” but also “where am I?” By wiring ADC activity to proteases, pH, and other TME cues, these designs are making […]
1. Experimental Design: (D) Ab-Fluor: The Perfect Pair
Don’t guess on your flow panel. In this article, Aditi Sharma explains the golden rules to select the right antibody-fluorophore conjugates, essential for accurate data and high signal resolution. Stop guessing and start resolving! (Click anywhere on the image to expand) Disclaimer The editors take care to share authentic information. In case of any discrepancies […]
ONCOMINE DX EXPRESS TEST
In this edition, Krishnangi examines the Oncomine Dx Express Test, a recently FDA-approved next-generation sequencing assay designed to accelerate precision oncology. Through her coverage, she outlines the assay’s integrated sequencing workflow, its role as a companion diagnostic in lung cancer, and its broader potential to expand access to rapid, high-complexity tumor profiling across diverse clinical […]
Leading the ADC Breakthrough in TNBC: Trodelvy
In this edition of ADC Spotlight, Sneha explores Trodelvy, the Trop-2 directed Antibody-Drug Conjugate that transformed treatment for triple-negative breast cancer (TNBCs)and expanded ADC potential across solid tumors. This snapshot captures its story from development to impact, underscoring how Trodelvy continues to define the promise of targeted cytotoxic therapy. (Click anywhere on the image to […]
Self-Immolative and Traceless Linkers: How Chemistry Turned One Antibody into Multiple Blockbusters
Self‑immolative and traceless linkers are rapidly becoming one of the most powerful “hidden” levers in ADC design, quietly transforming a single antibody scaffold into multiple distinct medicines and unlocking payloads once considered too toxic to use. In this Medness Spotlight, Suhail Ahmed Kabeer walks through how these vanishing linkers work, why the trastuzumab platform (Kadcyla, […]
How New Advances in Alzheimer’s Treatments Are Changing the Disease Landscape
In this NeuroHorizons edition, Neeba Wilson explores how advancements in Alzheimer’s treatments are rebuilding the landscape of this devastating disease via events such as the approval of LEQEMBI® (lecanemab). Recently approved by Health Canada in October 2025, LEQEMBI represents a shift toward treating the underlying causes of Alzheimer’s, rather than its symptoms alone. This article […]
The Evolution of ADC Linkers: Timers and Triggers for Precision Therapy
How did a “simple chemical bridge” become the deciding factor for every successful ADC? In this Medness feature, Suhail Ahmed Kabeer Rasheed reveals why the linker – acting as timer and trigger – controls how, when, and where a cytotoxin is delivered in real-world cancer therapy. Tracing the field’s evolution from brittle bonds to programmable […]
1. Experimental Design: (C) Antibody Selection
Choosing the right antibody is the foundation of high-quality flow data, but the options can be overwhelming. In this article, Aditi Sharma provides an essential guide to navigating the critical criteria for selecting antibodies for flow cytometry. (Click anywhere on the image to expand) Disclaimer The editors take care to share authentic information. In case […]
How do Our Neural Networks Respond to Mental Exhaustion?
In this article, Neeba Wilson explores the emerging neuroscience behind why our brains sometimes buzz with focus and other times drag with mental exhaustion. Drawing on a recent report in Scientific Reports, discover how intricate networks across the prefrontal cortex, motor regions, and other neural hubs reorganize under cognitive strain. Learn how low-order networks falter […]
Powering Precision Through Combination Therapy: Polivy
In this edition of ADC Spotlight, Sneha explores Polivy, a CD79b-directed Antibody-Drug Conjugate that advanced targeted therapy in diffuse large B-cell lymphoma (DLBCL). By harnessing selective B-cell targeting and combining with established chemoimmunotherapy backbones, Polivy offers renewed hope for patients with relapsed or refractory disease. This snapshot captures its story from development to impact, highlighting […]
Site Specific Conjugation: The Chemistry Quietly Powering Next Generation ADCs
After decoding how next-gen antibody formats—biparatopic, tetravalent, bispecific—reshaped the front end of ADC targeting, this Medness feature asks: what happens after you’ve built the “smartest” antibody possible? The answer is chemistry. In this installment, Suhail Ahmed Kabeer Rasheed explores how site-specific conjugation—once a technical afterthought—is now quietly powering the most precise, potent, and reliable ADCs ever made. […]
1. Experimental Design: (B) Instrument First
Before a single antibody is chosen or a cell is stained, a deep understanding of your instrument’s unique optical setup – its lasers, mirrors, and filters – is paramount. In this chapter, Aditi Sharma illuminates why “knowing your instrument” is the non-negotiable first step. (Click anywhere on the image to expand) Disclaimer The editors take […]
Bispecific ADCs: From Precise to “Ultra-Precise”
How did the field move from classic “one-antigen-one-payload” ADCs to the new frontier of bispecific ADCs—and why does it matter for patients? In this Medness feature, Suhail Ahmed Kabeer explores how parallel innovations – like biparatopic, tetravalent, and bispecific platforms – emerged to tackle longstanding challenges of tumor heterogeneity, antigen loss, and off-tumor toxicity. Discover […]