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Verastem Oncology obtained worldwide development and commercialization rights to the RAF/MEK inhibitor CH5126766 (CKI27) from Chugai
“Based on the single-agent defactinib results in KRAS mutant NSCLC, we conducted an internal pre-clinical effort to identify drug classes that were synergistic with defactinib and saw the highest level of synergy in combination with MEK inhibitors and, specifically, with CH5126766,” said Dan Paterson, President and Chief Operating Officer of Verastem Oncology. “The exciting early clinical results led to our decision to enter into a partnership with Chugai for CH5126766 and accelerate the combination development program for patients with KRAS mutant cancers, which are highly aggressive and recurrent. We plan to initiate discussions with regulatory authorities about our development plans and to define the registration path early this year.”
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FORMA reports achievement of early-stage clinical development milestones for assets licensed exclusively to Boehringer Ingelheim and Bristol-Myers Squibb
Frank Lee, CEO of FORMA said, "FORMA has a deep history of collaboration, and I’m excited about the achievement of these clinical milestones announced today. Our partnership with BI was among the early drug discovery initiatives focused on difficult-to-drug protein-protein interactions in cancer. We are gratified to see this pan-KRAS inhibitor, which BI licensed following early discovery work by FORMA, advance into the clinic and potentially offer a much-needed new therapy for patients with limited treatment options."
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Sanofi announces the successful acquisition of Synthorx Inc.
Sanofi announces the successful acquisition of Synthorx, Inc. for $68 per share in cash. Sanofi completed this acquisition through the merger of Purchaser (its wholly owned subsidiary Thunder Acquisition Corp.) with and into Synthorx thus the latter becoming a surviving corporation and becoming an indirect and wholly owned subsidiary of Sanofi.
“The acquisition of Synthorx perfectly aligns with our R&D strategy, enhancing our position as an emerging leader in the area of oncology and immunology,” says Paul Hudson, Chief Executive Officer, Sanofi. “We gain access to both great scientists and science with THOR-707, an engineered not-alpha IL-2 for the treatment of solid tumors which induces strong immunological responses in vivo, additional intriguing pre-clinical assets, and a powerful platform that complements our ongoing oncology and immunology research.”
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