CAHn you do it?
Crinecerfont can improve CAH What is CAH and its cause? In response to stress, the body releases CRH (corticotropin-releasing hormone) from the hypothalamus, which signals the pituitary gland via CRF1 (corticotropin-releasing hormone receptor 1) to produce ACTH (adrenocorticotropic hormone). ACTH further stimulates the adrenal gland present over the kidney to synthesize cortisol, aldosterone, and androgens […]
Your Face Can Predict Metabolic Disorders
A team of scientists from Beijing, China have developed a thermal face image analysis program called ThermoFace (TF) that could predict biological age and metabolic disorders with 80-90% accuracy. They trained their program on thermal and 2D visible images of 2,811 Han Chinese individuals – 1,339 females and 1,472 males. They made a face mesh, […]
Let’s MASHup!!
MASH (Metabolic dysfunction associated steatohepatitis) is a severe form of non-alcoholic liver disease, previously known as NASH (Non-alcoholic steatohepatitis). It is caused by increased fat deposits and inflammation in the liver despite low alcohol consumption. This further leads to liver scarring called cirrhosis. Untreated cirrhosis causes irreversible damage to the liver leading to its failure […]
A Ray of Hope- Islets transplantation for T2D patients too
Islets are a group of hormone producing cells that control blood glucose levels. Islet transplantation is considered a cure for type 1 diabetes (T1D). T1D is caused by the destruction of beta cells in islets by the body’s immune system. These beta cells produce insulin that decreases blood glucose. Islet transplantation is challenging due to […]
Alkaline Phosphatase: Potential cure for acute kidney injury?
Acute kidney injury (AKI) affects 20-50% of all hospitalized patients. It is characterized by an increase in serum creatinine and decreased urine output. AKI has mortality rate of >50%. Many factors are responsible for AKI like trauma, cardiovascular surgery, administration of nephrotoxic drugs, but sepsis associated AKI is the prominent one. Current treatment plans include […]
Mito!! Give me the power to rejuvenate!
We all know that mitochondria are the powerhouse of cells because they generate energy from food. However, we did not know their involvement in cellular regeneration. Scientists at UT Southwestern Medical Center determined that liver cells with damaged mitochondria have less ability to regenerate when injured. Henceforth, allowing cells with undamaged mitochondria to grow more, […]
Insulin Efsitora Alfa-Substitute for Continual Insulin Administration
Eli Lilly Efistora has showed positive outcomes from QWINT-2 and QWINT-4 phase 3 clinical trials. The trials discerned impact of the once weekly insulin efsitora in patients with T2 diabetes using insulin for the first time. The trials compared results with patients requiring multiple daily insulin injections. Although results of efsitora consumption are not superior […]
Lixisenatide has added benefits for treating Parkinson disease
New Diabetic Drug Lixisenatide has found its new purpose to treat Parkinson disease. The studies published in New England Journal of Medicine suggested that lixisentide therapy attenuated the progression of motor disability in patients diagnosed with Parkinson disease in less than 3 years (Meissner et al., 2024). These benefits were associated with gastrointestinal side effects. […]
Wegovy is the New Weight Loss Superstar to Win FDA Approval
Novo Nordisk, already popular weight loss med Wegovy, added another feather in its cap. NOVO’s SELECT cardiovascular outcome showed a 20% reduction in CV events. The study was conducted for five years on 17,604 patients who were obese or overweight. The trial was initiated in 2018. The FDA nod was based on the results of […]
Novo Weight Loss Drug Semaglutide (Ozempic’s) Reduces Kidney Disease Progression
Novo Semaglutide, aka Ozempic, has added another feather to the cap besides reducing body weight. Ozempic has been shown to reduce the progression of chronic kidney disease (CKD). The FLOW trial has shown that administration of Semaglutide (1.0 mg) reduces the risk of kidney disease-related problems in patients suffering from type 2 diabetes. This reduction is 24 […]
Versatile “Zepbound” by Eli Lilly Became the First Weight Loss Drug Approved by the FDA
Food and Drug Administration (FDA) approved ZepboundTM (Tirzepatide) for weight management in 2023. This twincertin compound is approved for controlling blood sugar in patients suffering from T2DM. Trizepatide is a precise amalgamation of the glucose-dependent insulinotropic polypeptide (GIP) and Glucagon-like peptide (GLP-1) receptors and has added advantage over Semaglutide, Liraglutide, Dulaglutide (agonist or activators of […]
