“We are extremely pleased with the positive interim data, especially the 7.4 month mPFS in the ZFA cohort of heavily pretreated patients, which builds on the responses reported earlier and underscores the potential of zotatifin as a promising treatment option for patients with ER+ metastatic breast cancer,” said Steve Worland, Ph.D., president and chief executive officer of eFFECTOR. “The safety and tolerability data are also encouraging and have led us to reopen dose escalation of the ZFA triplet.”