How far can antibody engineering take ADCs—and what challenges stand in the way? In this new MedNess feature, Suhail Ahmed Kabeer Rasheed examines the leap from biparatopic to tetravalent antibody-drug conjugates, unpacking how higher valency is tackling tumor heterogeneity and internalization resistance.
Discover why tetravalency has become the next frontier after biparatopic platforms: what it means for clustering, trafficking, efficacy, and how tuning valency and payload is central to future ADC innovation. What lessons does the first tetravalent clinical data (MEDI4276) offer – and where are the next smart designs heading?
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