In this week’s ADC Spotlight, Suhail Ahmed Kabeer Rasheed unpacks Fc‑glycan–directed ADCs—the site‑specific, hydrophilic conjugation platforms quietly powering a growing class of antibody–drug conjugates. Using HMBD‑501’s first‑in‑human milestone as a timely hook, he explains how enzymatic glycan remodelling and metal‑free click chemistry turn the Fc sugar into a portfolio‑wide docking hub, and highlights clinical gsADCs like ADCT‑601, XMT‑1592, MRG004a, IBI343 and JSKN003 that are already showing gains in homogeneity, PK and therapeutic index over conventional ADCs.
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