In this article, Neeba Wilson explores the emerging science behind how Parkinson’s disease may begin years before its hallmark motor symptoms appear. Drawing from new research published in October 2025, learn how early brain inflammation, activated microglia, and immune system changes inside and outside the brain set the stage for neuronal damage. Learn how alpha-synuclein aggregation, gut inflammation, genetic risk factors, and peripheral immune signals converge to drive disease progression and why these hidden processes could unlock earlier diagnosis and preventive therapies.
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