In this article, Neeba Wilson explores the emerging neuroscience behind why our brains sometimes buzz with focus and other times drag with mental exhaustion. Drawing on a recent report in Scientific Reports, discover how intricate networks across the prefrontal cortex, motor regions, and other neural hubs reorganize under cognitive strain. Learn how low-order networks falter then rebound, why high-order networks shift dramatically during prolonged effort, and what this means for detecting and even preventing mental fatigue. 

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