“Can antibodies be purposefully engineered for ADC success, or does ‘any antibody will do’? This week on MedNess, our ADC Spotlight series challenges the early assumption that repurposed therapeutic antibodies automatically make effective ADC scaffolds – revealing why internalization efficiency, not just target binding, determines clinical outcomes.
In this feature, Suhail Ahmed Kabeer Rasheed, PhD, explores how the industry evolved from ‘any antibody’ approach to today’s precision-engineered biparatopic platforms. Learn how biparatopic antibodies like JSKN003 achieve 68.8% response rates where standard ADCs plateau at 38%, why IMGN151’s purpose-built design delivered 200-fold potency improvements, and what the future holds as tetravalent formats push the boundaries of ADC engineering – proving that antibody scaffolds matter just as much as payloads.”
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